...because one of the two must typically be sacrificed when traveling. Sure, you could take a plane, and sacrifice a small fortune (by my standards). Or, you could take a Greyhound Bus and sacrifice your comfort. Comfort can be regained; after you step off the bus at your destination, you can eventually lie down and finally stretch your legs. Money is not so easily gotten back.

I have ridden the Greyhound bus about 10 times.

Greyhound pros
CHEAP. Yes, probably the cheapest means of travel out there. Of course, you do only get what you pay for, and at times during the trip you are likely to wonder if you're even getting that much.
NICE FOR A BUS. Think back to the school bus. Ugh. Well, kids, Greyhound busses have padded, vaguely attractive seats with armrests. You can lean back in these seats. There are overhead storage compartments. There is even a semblance of a restroom on board (again, you get what you pay for--don't say I didn't warn you). Heck, you can even bring food and beverages on the bus, and if you drop your bottle of Sprite it will roll around on the floor until some friendly Greyhound employees clean the bus out.

Greyhound cons
NOISY. The bus is often noisy. The stations are virtually always noisy. Most of the time, the bus quiets down at night, but there are sometimes passengers that are incapable of respecting others' sleep and use their outdoor voices generously.
UNCOMFORTABLE. This is probably about as comfortable as a bus can get, but you will still be cursing it after half a day. You will probably be too tired and hazy to curse it after three days (yes, I have ridden this long). Sometimes the bus is not too crowded and you can lay down in your seat. It's at its worst when you are in the aisle seat and have another passenger sitting next to you. When sleep sets in, you still must be careful to avoid spilling out into the aisle, and to avoid dozing on the shoulder of the stranger next to you.
Also, I have seen a few lucky folks stand in the aisle for several hours until seats opened up (it is very, very rare for it to be that crowded though).
A pillow will make all this more bearable.
LONG LAYOVERS. Sometimes you must wait an hour, or a few hours, to get back on the bus or to transfer busses.
CREEPS. There are always creeps. Avoid those who strike you as blatantly creepy. Do stay close to your luggage, keep it in sight. I prefer not to interact with people unless I definitely get a "I'm a nice, normal person" vibe from them.
SOMETIMES RUDE EMPLOYEES. I'd be disgruntled and a little cranky if I were working for Greyhound, wouldn't you? It is a pleasant surprise though to encounter a nice Greyhound employee.
CONFUSING SYSTEM. Not all stations use all the same systems. Sometimes you must transfer your own baggage, sometimes employees do it for you. If they are transferring your stuff, keep an eye on it and make sure it's going to the same bus as you are. I lost a bag one time, due simply to my own lack of observation, but it was found and arrived at my destination a day after I did. There are many strange and baffling nuances that you slowly learn with experience. Do ask for help at the information desk. I tried to ask a janitor for help once and was met with a death stare.

Other stuff
BAGGAGE. You can take two carry-on bags aboard the bus. I think you can usually get away with taking on more or bigger stuff than they allow, but I wouldn't count on it. You can have two other pieces of luggage stowed under the bus. If you have more luggage than that, it's an additional charge of around $10 per bag.
FOOD. If at all possible, try to bring your own food. The food available at stations and rest stops varies from vending machines to cafes, but it's always insanely overpriced. Sometimes the bus will stop at a McDonald's.
STOPPING. The bus will do a variety of stopping, from long layovers to five minute breaks. It stops at large stations, small stations located in family-owned stores, rest stops with food and gift shops. If the bus isn't going to be stopping long, stay close to it if you get out.

At greyhound.com you can find out more about it, see schedules and prices, and reserve tickets.

Recommended: Yes