Pfizer Revolution (Selamectin)

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Border Collies are sensitive to Revolution

Jan 12, 2010
Review by  
Rated a Very Helpful Review

Pros:sorry i don't have any

Cons:can kill your dog, cost you a fortune.  unsure about Pfizer's post marketing responsibility.

The Bottom Line: Please do not use this product if you have border collies or other herding breed dogs.  You may lose your pet.


I treated our purebred Border Collies with Revolution as a preventative for heartworm.  We normally would use this drug from June through November.  I administered 6.0 mg per Kg to our dogs topically late afternoon.  The following morning one of our dogs staggered out of her kennel, had a fever, lethargy, refused to eat and developed tremors, tachypnea 45-60/minute.  She had many vet visits; IV fluids, antibiotics, steroids etc.  I was force feeding her chicken broth and watered down baby food.  She was dehydrated and very weak.  We thought she was going to die.  Our first vet gave up and sent us home with a very poor prognosis and with instruction for me to administer sub-cutaneous fluids.  I took our dog to another vet for a second opinion and he started over.  She did not respond to any treatment other than supportive measures.  After 12 days, she finally turned around and on day 14 we took her home totally back to normal eating like a horse and wanting to play.  During this time I found out about the sensitivity some border collies have to P-glycoprotein-substrate drugs.  The reason for this is due to a MDR1 gene mutation which allows the drug to cross the blood brain barrier leading to toxosis.  Studies have shown a majority of Border Collies have this genetic defect and are at risk.
I am currently trying to get Pfizer to pay for our vet bill which was in access of $2100.00.
Please, don't use this product if you have a Border Collie.  Other dogs of the herding breeds are also at risk.


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